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| Ticker | Owner | Relationship | Date | Transaction | Cost | #Shares | Value ($) | #Shares Total | SEC Form 4 |
|---|---|---|---|---|---|---|---|---|---|
| IONS | BENNETT C FRANK | EVP, Chief Scientific Officer | Jul 07 '26 | Sale | 84.95 | 20,536 | 1,744,623 | 0 | Jul 09 |
| IONS | BENNETT C FRANK | EVP, Chief Scientific Officer | Mar 03 '26 | Option Exercise | 53.73 | 65,089 | 3,497,531 | 165,643 | Mar 05 |
| IONS | BENNETT C FRANK | EVP, Chief Scientific Officer | Mar 03 '26 | Sale | 79.23 | 85,089 | 6,741,669 | 80,554 | Mar 05 |
| IONS | BENNETT C FRANK | EVP, Chief Scientific Officer | Feb 02 '26 | Option Exercise | 53.73 | 65,089 | 3,497,531 | 128,919 | Feb 04 |
| IONS | BENNETT C FRANK | EVP, Chief Scientific Officer | Feb 02 '26 | Sale | 82.79 | 36,463 | 3,018,877 | 80,293 | Feb 04 |
| IONS | BENNETT C FRANK | EVP, Chief Scientific Officer | Jan 30 '26 | Sale | 82.95 | 5,885 | 488,141 | 100,293 | Feb 02 |
| IONS | BENNETT C FRANK | EVP, Chief Scientific Officer | Jan 16 '26 | Sale | 75.15 | 8,977 | 674,622 | 94,757 | Jan 20 |
| IONS | BENNETT C FRANK | EVP, Chief Scientific Officer | Jan 15 '26 | Option Exercise | 0.00 | 21,055 | 0 | 103,734 | Jan 20 |
| IONS | BENNETT C FRANK | EVP, Chief Scientific Officer | Sep 05 '25 | Sale | 59.60 | 6,000 | 357,581 | 82,679 | Sep 09 |